On the last Sunday of October, at 3 a.m., clocks fall back one hour. This shift to winter time is often presented as the gentler of the two, the one that "gives" an extra hour of sleep. Studies confirm it is better tolerated than the spring change, but they nuance the picture: in Denmark, over 18 years of records, it was followed by an 11% increase in hospital contacts for a depressive episode, which dissipated in about ten weeks.
This guide brings together what studies identified via PubMed show about the biological clock, sleep, the heart, the road, and mood, always separating autumn from spring, then what helps, from morning light to melatonin. A practical 7-day protocol concludes the article.
What the studies show : the shift to winter time is better tolerated than the shift to summer time. The risk of heart attack is slightly elevated after the spring change (relative risk of 1.04 to 1.05 according to two meta-analyses), not after the autumn change. In a large American study, fatal accidents are 6% more common after the shift to summer time, with no effect noted in autumn. Autumn has its own signals, more subtle: complaints of insomnia, pedestrian accidents at dusk, temporary increase in depressive episodes in Denmark. These are associations, not proof of cause and effect.
What helps : gradually shift bedtime and meals, maintain a regular wake time, seek daylight, limit bright light and caffeine in the evening. Against seasonal depression, light therapy has the strongest support: in a trial of 96 patients, 30 minutes at 10,000 lux each morning produced 67% responders, as many as fluoxetine. Meta-analyses on vitamin D are discordant, and no trial on melatonin has addressed the time change itself.
- Winter time: what really changes
- Biological clock, light, and melatonin
- Why autumn is better tolerated than spring
- Sleep in the following days
- Heart, stroke, road: autumn versus spring
- Winter time and mood: the Danish signal
- Chronotypes, children, adolescents, and seniors
- Seasonal blues: light therapy and vitamin D
- Melatonin: what the trials show
- Caffeine, screens, exercise, meals: daily levers
- Eliminating the time change: what chronobiologists say
- The 7-day protocol
- Frequently Asked Questions
Standard Time: What Really Changes
The shift to standard time occurs on the last Sunday of October : at 3 a.m., it becomes 2 a.m. again. Researchers refer to a return tostandard time, the time that most closely approximates solar time; daylight saving time, in spring, advances clocks by one hour relative to it.
The next day, an alarm ringing at 7 a.m. corresponds to 8 a.m. old time: mornings are brighter, but night falls an hour earlier upon returning from work. Since days are already getting shorter, it is difficult to separate the effect of the time change from that of the season: some of the increases attributed to the time change disappear when compared with regions that do not change their clocks.
Nearly all compare heart attacks, accidents, or hospitalizations in the days following the change to those in neighboring weeks. These registries, often very large, show associations, not causes.
Biological Clock, Light, and Melatonin
Thecircadian clock organizes hunger, sleep, and alertness over approximately 24 hours, and resets each day thanks to light. According to a position statement by chronobiologists, daylight is generally 100 to 1,000 times more intense than indoor lighting, making it far more effective for resetting the clock.
<<<26>>> Melatonin mélatonine is the hormone that signals nighttime. Its secretion begins in the evening in dim light and stops in bright light, and household lighting is enough to disrupt it: in 116 volunteers aged 18 to 30, indoor lighting below 200 lux in the 8 hours before bedtime, compared to dim light below 3 lux, delayed the onset of secretion in 99% of them and shortened its duration by approximately 90 minutes.
In a survey of 55,000 people, sleep time on free days followed the seasonal progression of dawn under standard time, but not under daylight saving time. In 50 volunteers followed for 8 weeks around each time change, sleep and activity adjusted easily upon returning to standard time in autumn, whereas activity time did not adjust to daylight saving time in spring, especially in "evening people."
Kantermann T, Juda M, Merrow M, Roenneberg T. Curr Biol 2007;17(22):1996-2000. DOI: 10.1016/j.cub.2007.10.025
Bright evening light shifts the clock later: in a laboratory trial, reading on a backlit e-reader before sleep, rather than a printed book, delayed sleep onset and the clock, reduced melatonin, and decreased alertness the next morning.
Why Autumn Is Better Tolerated Than Spring
In spring, one must wake an hour earlier for the biological clock, in the dim morning light that returns: this is a net loss of sleep and, over 8 weeks of follow-up published in Current Biology, activity time did not adjust to it, especially in "evening people." In autumn, the alarm falls an hour later for the internal clock, and the same follow-up shows easy adjustment.
A British learned society on sleep concludes, in a position statement published in 2025, that circadian health and sleep are negatively affected by imposed time changes, especially forward shifts, thus in spring, and positively affected by natural morning light. A systematic review of 27 studies points in the same direction, with heterogeneous results: shorter and poorer sleep, increased drowsiness, especially in spring and in "evening people."
Autumn is not neutral either. A reference review emphasizes that the hour gained is hardly recovered in sleep on the night of the change, and that five consecutive days of earlier clock-based wake times can result in a net loss of sleep over the week.
After the switch to standard time, it is one hour earlier on the clock than what your body believes: you risk feeling sleepy earlier in the evening and waking up earlier in the morning, until your internal clock has adjusted one hour later.
Sleep in the following days
In 11,780 British adults aged 43 to 78, sleep duration on the Sunday of the standard time change exceeded that of the previous Sunday by 33 minutes and the following Sunday by 38 minutes. On the Sunday of the daylight saving time change, it was 65 minutes shorter than the previous Sunday. A slight sleep rebound followed both changes, less pronounced in autumn.
de Lange MA, Richmond RC, Birnie K, et al. J Sleep Res 2025;34(3):e14335. DOI : 10.1111/jsr.14335
This study compares different people from one Sunday to another, a limitation acknowledged by its authors. In a Canadian cohort of 30,097 people aged 45 to 85, those interviewed the week following the standard time change reported more often being dissatisfied with their sleep than those interviewed the previous week (28% versus 22.6%). They reported more difficulty falling asleep (7.1% versus 3.3%), more bothersome nighttime awakenings (12.9% versus 8.2%), and more daytime sleepiness (7.3% versus 3.6%). In spring, only a 9-minute reduction in sleep duration appeared. The authors describe a transient increase in sleep disorders after the switch to standard time.
How long does adaptation take? No study provides a universal figure: the autumn adjustment is described as easy, and the increase in complaints occurs in the first week. As an estimate, not a study result, count on anywhere from a few days to one week.
Heart, stroke, road: autumn versus spring
Myocardial infarction. A 2019 meta-analysis (7 studies, over 115,000 people) found a modest but significant increase in risk after the spring daylight saving time change (odds ratio 1.05) and risk comparable to control periods the week following the autumn standard time change (1.01, not significant). The 2024 meta-analysis (12 studies, 10 countries) confirms: relative risk of 1.04 in spring, 1.02 in autumn, not significant, reduced to 1.00 after excluding one inconsistent study. However, an Andalusian registry noted an observed-to-expected ratio of 1.06 for myocardial infarction around the autumn time change, just barely significant: an isolated regional signal.
Stroke. In Finland, from 2004 to 2013, hospitalizations for ischemic stroke increased by 8% during the first two days following time changes, analyzed together, but not over the entire week; the increase reached 20% in those over 65 years old.
Road. Among 732,835 fatal accidents recorded in the United States from 1996 to 2017, the spring daylight saving time change was associated with a 6% increase in risk, especially in the morning, with no effect at the return to standard time. A 2026 analysis, which compares with two states that do not change their clocks, no longer finds an overall effect, but an increase of approximately 26% in morning fatal accidents after the spring change, and suggests that the apparent autumn effect is mainly due to the season itself.
In the United States, from 2010 to 2019, fatal accidents involving vehicle occupants decreased by 7.1% in the 5 weeks following the standard time change, while those involving pedestrians and cyclists increased by 13%. In spring, it was the opposite: +12% for occupants, −24% for pedestrians and cyclists, variations strongly linked to lighting conditions for pedestrians and cyclists, much less so for occupants.
Woods AN, Weast RA, Monfort SS. J Safety Res 2025;93:200-205. DOI : 10.1016/j.jsr.2025.02.010
Its authors work for a road safety research institute linked to the insurance sector. A review of 157 studies conducted in 36 countries associates the switch to standard time, each time based on a single high-quality study, with a decrease in all-cause mortality and workplace accidents, but also with more physical assaults.
| Effect studied | After daylight saving time | After standard time | Level of evidence |
|---|---|---|---|
| Myocardial infarction | Relative risk of 1.04 to 1.05 | 1.00 to 1.02, not significant; isolated signal in Andalusia | Two meta-analyses of observational studies |
| Ischemic stroke | +8% the first two days, both changes analyzed together | Same combined analysis, no increase over the week | One Finnish national registry |
| Fatal accidents | +6%, especially in the morning; overall effect null with control group | No overall effect; +13% for pedestrians and cyclists | Large American registries, results sensitive to methodology |
| Sleep | −65 minutes on Sunday, increased drowsiness | +33 minutes on Sunday, more complaints of insomnia afterward | Accelerometers and large cohort |
| Depressive episodes | No change | +11%, resolved within approximately ten weeks | Danish national registry, findings not consistently replicated |
| All-cause mortality | No change (one American study) | Approximately 2.5% lower, single high-quality study | Systematic review of 157 studies, variable quality |
Winter time and mood: the Danish signal
Among 185,419 hospital contacts for unipolar depression recorded in Denmark from 1995 to 2012, the transition from daylight saving time to standard time was associated with an 11% increase (95% confidence interval 7 to 15%) in their frequency, which resolved within approximately ten weeks. The transition to daylight saving time was not associated with any comparable change.
Hansen BT, Sønderskov KM, Hageman I, et al. Epidemiology 2017;28(3):346-353. DOI: 10.1097/EDE.0000000000000580
These are fairly severe depressions leading to hospitalization. The authors propose a hypothesis: the sudden advance of sunset, which opens a long period of short days, may be experienced as a shock. The review of 157 studies found no clear and consistent effect on mental health.
A good reason to pay attention to your mood in November. Our guide on mental fatigue helps distinguish temporary fatigue from a condition warranting medical consultation.
Consult your doctor if sadness, loss of interest, feelings of worthlessness, sleep or appetite disturbances persist, worsen, or impact your life. Depression, even seasonal, is treatable through light therapy, psychotherapy, or antidepressants depending on the case. If you have suicidal thoughts, call 3114 or 15.
Chronotypes, children, adolescents, and seniors
"Evening" or "morning" types. Chronotype refers to the time at which your internal clock naturally places sleep. "Evening" types are most affected in spring, as shown by Current Biology monitoring and a review of 27 studies. In autumn, this is an untested hypothesis in these studies: setting the clock back could bring them closer to their natural rhythm, and very "morning" types risk waking up early on the first few days.
Adolescents. Naturally more "evening" types, they showed increased daytime drowsiness after the transition to daylight saving time, up to the third week, more so in older and more "evening" adolescents. We found no equivalent data for winter time.
Babies and young children. We identified no studies on infants. In practice, adjust bedtime, meals, and naps by 10 to 15 minutes per day in the week before or after, and expose them to daylight in the morning: this is practical advice, not a study finding.
Seniors. The sleep studies cited above involved adults aged 43 to 85, who reported more insomnia in the week following the transition to winter time; in the Finnish registry, combining both time changes, the increase in strokes in the first two days reached 20% after age 65. Regular schedules and outdoor time in daylight remain good practical recommendations.
Seasonal depression: light therapy and vitamin D
<<<38>>> Seasonal depression dépression saisonnière is a recurring depression that develops in autumn or winter and disappears in spring. Its prevalence ranges from 1% to 10% depending on latitude and measurement methods; it is more common in women and younger people, and more represented in bipolar disorder. Only a healthcare professional can make the diagnosis. A review of 11 studies notes heavier dinners and increased cravings for starches in patients; our analysis of sugar and sleep details this cycle.
Light therapy consists of exposing yourself daily, with eyes open, to a very bright lamp. A 2005 meta-analysis attributed a large effect to it in seasonal depression (effect size of 0.84 across 8 trials); by convention, 0.2 corresponds to a small effect, 0.5 to a medium effect, and 0.8 to a large effect. A more recent meta-analysis (lamps of at least 1,000 lux versus light of 400 lux or less) finds a more modest but significant effect (−0.37, 18 trials, 610 patients), with studies of variable quality.
In 96 patients with seasonal depression, 8 weeks of 10,000 lux light, 30 minutes each morning, with a placebo capsule, produced the same response rate (67%) as fluoxetine 20 mg daily combined with placebo light of 100 lux. The light worked faster at one week and caused less agitation, sleep disturbances, and heart palpitations.
Lam RW, Levitt AJ, Levitan RD, et al. Am J Psychiatry 2006;163(5):805-812. DOI : 10.1176/ajp.2006.163.5.805
Blue light lamps have not shown efficacy against inactive light in a meta-analysis of 9 trials. Going outside in the morning does not replace treatment when depression is established.
Vitamin D is synthesized by the skin under the effect of sunlight, hence the idea of a link with mood in winter. Meta-analyses are conflicting. The one of 31 trials and 24,189 participants finds a small decrease in depressive symptoms per 1,000 IU per day (−0.32), more marked in already depressed individuals (−0.57), but only in short trials: beyond 24 weeks, the effect is no longer significant. In elderly people, 11 studies and 21,561 participants show no significant effect (−0.10). And for seasonal depression, a systematic review concludes that no nutritional intervention tested, including vitamin D, has shown benefit.
Vitamin D maintains its place in winter to cover needs when sunlight is scarce, as explained in our guides on vitamin D deficiency and on when and how to take it; based on current trial evidence, we cannot attribute an effect on seasonal low mood. Our Plant-based Vitamin D3, presented at the beginning of the article, provides 1,000 IU per drop, at a rate of 2 drops per day during a meal in adults. In case of pregnancy or breastfeeding, consult a healthcare practitioner.
Saffron has been studied in adults without diagnosed depression. In a British trial, 56 adults aged 18 to 54 with low mood or stress took 30 mg per day (two 15 mg capsules) of a standardized extract for 8 weeks: their depression scores decreased more than under placebo. In a trial from a German university, in 165 adults suffering from moderate insomnia, 20 or 30 mg of the same extract for 4 weeks reduced insomnia symptoms slightly more than placebo. In this second trial, the extract was taken in the evening, approximately one hour before bedtime. These trials involve the extract from our Saffron, dosed at 30 mg per capsule and to be taken in the morning with a meal, and count among their authors employees of its manufacturer; none addresses the time change nor seasonal depression. Our article on saffron and sleep details them. Saffron is not recommended during pregnancy, breastfeeding and before age 12, and requires medical advice when taking antidepressants, anxiolytics, or anticoagulants.
Melatonin: what the trials show
When taken as a supplement, melatonin somewhat promotes falling asleep and can shift the clock, earlier or later depending on the time of intake.
In 9 out of 10 trials, melatonin taken near the target bedtime at destination, between 10 p.m. and midnight, reduced jet lag after flights crossing 5 time zones or more. Doses of 0.5 to 5 mg showed comparable efficacy, with faster falling asleep at 5 mg; a prolonged-release form of 2 mg proved minimally effective. Taken early in the day, it could cause drowsiness and delay adaptation.
Herxheimer A, Petrie KJ. Cochrane Database Syst Rev 2002;(2):CD001520. DOI : 10.1002/14651858.CD001520
In 34 adults aged 18 to 42, 0.5 mg of melatonin for 3 days produced maximum clock advance when taken in the afternoon, 2 to 4 hours before the natural onset of secretion, and delays when taken just after waking; the optimal time was later for 0.5 mg than for 3 mg. For falling asleep, a meta-analysis of 19 trials and 1,683 people suffering from primary sleep disorders finds modest effects: 7 minutes gained in falling asleep, 8 minutes more sleep, and a small improvement in sleep quality (0.22).
For the winter time change, the clock must reset later, whereas melatonin, taken before the natural onset of its secretion, advances it rather: it is therefore not, in itself, the tool for autumn resetting, and we found no trials on time changes. These results concern melatonin alone, at specific doses and at specific times, and do not transfer directly to other doses or other times of intake.
For melatonin in general, the 2002 review reports cases in people with epilepsy or taking warfarin, an anticoagulant: in these situations, consult a healthcare practitioner. Other options exist, such as glycine, presented in our glycine guide.
Caffeine, screens, exercise, meals: everyday levers
Caffeine. In a double-blind trial, the equivalent of a double espresso taken 3 hours before usual bedtime delayed the clock by approximately 40 minutes, almost half the effect of 3 hours of bright light at about 3,000 lux at bedtime. It also interferes with falling asleep: avoid coffee late in the day during the week of the time change. Our guide caffeine and sleep details its duration of action.
Screens and evening light. The evening extends under artificial light, which delays melatonin: dim lighting and screens in the hour before bedtime, as explained in our article on eye strain and screens.
Exercise. In 99 adults aged 18 to 30 and 59 to 75 years, one hour of moderate exercise on a treadmill, 3 days in a row, advanced the clock to 7 a.m. or between 1 and 4 p.m., and delayed it between 7 and 10 p.m. To support the fall clock adjustment toward later times, moderate activity in the evening, between 7 and 10 p.m. in this study, goes in the right direction, provided you don't schedule it too close to bedtime (practical tip).
Meals. In 10 young men, delaying meals by 5 hours for 6 days did not shift the central clock markers (melatonin, cortisol), but delayed blood glucose rhythm by nearly 6 hours. Gradually shifting breakfast and dinner times can thus help keep organ clocks synchronized, a practical tip derived from this data.
Alcohol and naps. We did not identify a specific study: as a practical tip, avoid compensating for a difficult evening with a drink, and prefer a short nap in early afternoon to a long late-afternoon nap. Magnesium is often associated with evening relaxation: our Magnesium+ combines microencapsulated magnesium oxide, magnesium malate, taurine and vitamin B6, at a dosage of 4 capsules per day; no trial has tested it for daylight saving time adjustment, and our article magnesium: morning or evening? helps you choose the best time to take it.
| Lever | Measured effect on the clock | Study |
|---|---|---|
| Indoor light in the evening, less than 200 lux | Melatonin delayed in 99% of volunteers, duration shortened by approximately 90 minutes | Gooley, 2011 |
| Double espresso 3 hours before bedtime | Clock delayed by approximately 40 minutes | Burke, 2015 |
| Moderate exercise at 7 a.m. or from 1 to 4 p.m. | Clock advanced | Youngstedt, 2019 |
| Moderate exercise from 7 to 10 p.m. | Clock delayed | Youngstedt, 2019 |
| Meals delayed by 5 hours | Blood glucose rhythm delayed by nearly 6 hours, central clock unchanged | Wehrens, 2017 |
Eliminating daylight saving time: what chronobiologists say
Eliminating time changes requires choosing between standard time, winter time, and permanent daylight saving time. The 2019 position of chronobiologists defends thepermanent standard time, which would eliminate the acute effects of changes such as the prolonged gap between social clock and solar clock imposed by daylight saving time. An American learned society of sleep medicine reaffirmed this in 2024, as did the British learned society mentioned above.
Out of 157 studies of variable quality conducted in 36 countries, the idea that time changes and daylight saving time would be uniformly harmful is not confirmed. Living on daylight saving time rather than standard time appears to be associated, in summer, with lower mortality and fewer road accidents, while standard time is potentially associated with shorter sleep in winter. The authors recommend a balanced approach.
Steponenaite A, Wallraff JP, Wild U, et al. Eur J Epidemiol 2026;41(4):419-433. DOI: 10.1007/s10654-026-01372-8
Learned societies agree on one point: the time changes themselves, especially in spring, strain the biological clock; the 2026 review invites consideration of their beneficial effects as well. In the meantime, winter time remains the easier of the two to navigate.
The 7-day protocol
This protocol, practical advice not tested as such, assembles the levers measured in studies to gently reset the clock.
Light therapy : medical advice beforehand in case of bipolar disorder, eye disease, or photosensitizing treatment. Melatonin in general : taking it at the wrong time can delay adaptation; reported cases in people with epilepsy or on warfarin warrant medical advice, as do, out of caution, pregnancy, breastfeeding, or ongoing treatment. Saffron : not recommended during pregnancy, breastfeeding, or before age 12; medical advice if taking antidepressants, anxiolytics, or anticoagulants. Vitamin D : practitioner advice during pregnancy or breastfeeding. Behind the wheel : during the changeover week, do not drive if you are struggling with sleepiness.
Vitamin D3 derived from lichen, 1,000 IU (25 µg) per drop, in organic virgin rapeseed oil: 2 drops daily with a meal, in a 20 ml dropper bottle.
View Vitamin D3For your winter mornings, our Saffron provides 30 mg of standardized saffranal extract per capsule, to be taken in the morning with a meal.
Frequently Asked Questions
When does the switch to winter time occur?
Every year, the last Sunday in October: at 3 a.m., it becomes 2 a.m. again.
What are the health effects of the time change?
After the spring forward transition, studies observe a modest increase in heart attacks and fatal accidents. After the fall back transition, there is no significant increase in heart attacks, but more complaints of insomnia the following week, more pedestrian accidents at dusk, and a temporary increase in depressive episodes in Denmark. These are associations.
Why does the time change cause fatigue?
Because the biological clock, regulated by light, does not shift instantaneously. For a few days, social time and internal time no longer coincide: you feel sleepy earlier in the evening, you wake up earlier, with sometimes less satisfying sleep.
How long does it take to adjust to winter time?
No study provides a universal figure. The autumn adjustment is described as easy, and the increase in insomnia complaints occurs in the first week.
Do we really sleep an extra hour with winter time?
Not quite. In 11,780 adults wearing an accelerometer, sleep was 33 minutes longer on the changeover Sunday than the previous Sunday.
Can the switch to winter time cause the blues?
In some people, yes. In Denmark, it was followed by an 11% increase in hospital contacts for depression, which subsided in about ten weeks; other studies do not find a consistent effect. If your mood declines persistently, consult your doctor.
Is light therapy effective against seasonal depression?
It is the best-supported treatment for seasonal depression. In an 8-week trial with 96 patients, 30 minutes of white light at 10,000 lux each morning produced a 67% response rate, comparable to fluoxetine.
Does vitamin D help with winter blues?
Meta-analyses are inconsistent: small reduction in depressive symptoms in short-term trials, more significant effect beyond 24 weeks, no effect in elderly people, and no proven benefit in seasonal depression. It remains useful in winter to meet daily requirements.
Should melatonin be taken during the time change?
No trial has addressed the time change. Melatonin reduced jet lag after flights crossing 5 or more time zones, taken between 10 p.m. and midnight at your destination, at doses of 0.5 to 5 mg.
How can you help a baby or child adjust to winter time?
We found no studies on infants. In practice, shift bedtime, naps, and meals by 10 to 15 minutes per day around the changeover, maintain regular routines, and provide daylight exposure in the morning.
Winter time or daylight saving time year-round: which is better for health?
Sleep science societies recommend standard time, winter time, year-round. A review of 157 studies calls for more nuance, with daylight saving time being associated with certain benefits in summer.
Sources
The studies cited below were identified via PubMed.
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- Lei D, Du Y, Peng S, Zhang M. Does daylight saving time increase road accidents? Seasonal confusion and impact on fatal morning accidents. Accident Analysis and Prevention, 2026;237:108719. DOI
- Roenneberg T, Wirz-Justice A, Skene DJ, et al. Why should we abolish daylight saving time? Journal of Biological Rhythms, 2019;34(3):227-230. DOI
- Gooley JJ, Chamberlain K, Smith KA, et al. Light exposure before bedtime suppresses the onset of melatonin secretion and shortens its duration in humans. The Journal of Clinical Endocrinology and Metabolism, 2011;96(3):E463-E472. DOI
- Kantermann T, Juda M, Merrow M, Roenneberg T. Seasonal adjustment of the human circadian clock is disrupted by daylight saving time. Current Biology, 2007;17(22):1996-2000. DOI
- Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening reading on a backlit e-reader impairs sleep, circadian rhythm, and next morning alertness. Proceedings of the National Academy of Sciences of the United States of America, 2015;112(4):1232-1237. DOI
- Crawford MR, Winnebeck EC, von Schantz M, et al. A British sleep society position statement on daylight saving time in the United Kingdom. Journal of Sleep Research, 2025;34(3):e14352. DOI
- Romigi A, Franco V, Scoditti E, et al. Effects of daylight saving time and clock changes on sleep and sleepiness: a systematic review. Sleep Medicine Reviews, 2025;84:102161. DOI
- Harrison Y. The impact of daylight saving time on sleep and associated behaviors. Sleep Medicine Reviews, 2013;17(4):285-292. DOI
- de Lange MA, Richmond RC, Birnie K, et al. Effects of clock changes on sleep duration measured by accelerometer in a large British cohort. Journal of Sleep Research, 2025;34(3):e14335. DOI
- Zolfaghari S, Cyr M, Pelletier A, Postuma RB. Effects of season and clock changes on sleep symptoms: the Canadian longitudinal study on aging. Neurology, 2023;101(1):e74-e82. DOI
- Schneider AM, Randler C. Daytime somnolence during the transition to daylight saving time in adolescents: are "evening types" at greater risk? Sleep Medicine, 2009;10(9):1047-1050. DOI
- Manfredini R, Fabbian F, Cappadona R, et al. Daylight saving time and acute myocardial infarction: a meta-analysis. Journal of Clinical Medicine, 2019;8(3):404. DOI
- Hurst A, Morfeld P, Lewis P, Erren TC. Time changes and risk of myocardial infarction. Deutsches Ärzteblatt International, 2024;121(15):490-496. DOI
- Rodríguez-Cortés FJ, Jiménez-Hornero JE, Alcalá-Diaz JF, et al. Time changes and cardiovascular disease in Andalusia: visibility graph time series modeling. Angiology, 2023;74(9):868-875. DOI
- Sipilä JO, Ruuskanen JO, Rautava P, Kytö V. Evolution of ischemic stroke incidence following time changes. Sleep Medicine, 2016;27-28:20-24. DOI
- Fritz J, VoPham T, Wright KP, Vetter C. Chronobiological assessment of acute effects of daylight saving time on road accident risk. Current Biology, 2020;30(4):729-735.e2. DOI
- Woods AN, Weast RA, Monfort SS. Daylight saving time and fatal accidents: the impact of changes in light conditions. Journal of Safety Research, 2025;93:200-205. DOI
- Steponenaite A, Wallraff JP, Wild U, et al. Systematic review of epidemiological studies on daylight saving time and health, identifying favorable and unfavorable effects. European Journal of Epidemiology, 2026;41(4):419-433. DOI
- Ambar Akkaoui M, Geoffroy PA. Screening and assessing seasonal depression: systematic review of available tools. Journal of Psychiatric Research, 2025;187:223-232. DOI
- Yang Y, Zhang S, Zhang X, et al. Role of diet, eating behavior, and nutritional interventions in seasonal depression: a systematic review. Frontiers in Psychology, 2020;11:1451. DOI
- Golden RN, Gaynes BN, Ekstrom RD, et al. Efficacy of light therapy in the treatment of mood disorders: review and meta-analysis. The American Journal of Psychiatry, 2005;162(4):656-662. DOI
- Pjrek E, Friedrich ME, Cambioli L, et al. Efficacy of light therapy in the treatment of seasonal depression: meta-analysis of randomized trials. Psychotherapy and Psychosomatics, 2020;89(1):17-24. DOI
- Lam RW, Levitt AJ, Levitan RD, et al. The Can-SAD study: randomized trial of the efficacy of light therapy and fluoxetine in winter seasonal depression. The American Journal of Psychiatry, 2006;163(5):805-812. DOI
- Do A, Li VW, Huang S, et al. Blue light in seasonal and non-seasonal depression: systematic review and meta-analysis of randomized trials. Canadian Journal of Psychiatry, 2022;67(10):745-754. DOI
- Ghaemi S, Zeraattalab-Motlagh S, Jayedi A, Shab-Bidar S. Effect of vitamin D supplementation on depression: systematic review and dose-response meta-analysis of randomized trials. Psychological Medicine, 2024;54(15):3999-4008. DOI
- Fu J, Zhang Y, Chen X, et al. Efficacy of vitamin D supplementation on depressive symptoms in elderly patients: meta-analysis of randomized trials. Frontiers in Medicine, 2024;11:1467234. DOI
- Jackson PA, Forster J, Khan J, et al. Effects of saffron extract supplementation on mood, well-being, and response to psychosocial stress in healthy adults: double-blind randomized trial. Frontiers in Nutrition, 2021;7:606124. DOI
- Schuster J, Mundhenke C, Nordsieck H, et al. Effect of saffron extract on sleep quality in adults with moderate insomnia: decentralized, randomized, double-blind placebo-controlled trial. Sleep Medicine: X, 2025;10:100147. DOI
- Herxheimer A, Petrie KJ. Melatonin for preventing and treating jet lag. Cochrane Database of Systematic Reviews, 2002;(2):CD001520. DOI
- Burgess HJ, Revell VL, Molina TA, Eastman CI. Human phase response curves to three days of daily melatonin: 0.5 mg versus 3.0 mg. The Journal of Clinical Endocrinology and Metabolism, 2010;95(7):3325-3331. DOI
- Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin in the treatment of primary sleep disorders. PLoS One, 2013;8(5):e63773. DOI
- Burke TM, Markwald RR, McHill AW, et al. Effects of caffeine on the human circadian clock in vivo and in vitro. Science Translational Medicine, 2015;7(305):305ra146. DOI
- Youngstedt SD, Elliott JA, Kripke DF. Human circadian phase response curves to exercise. The Journal of Physiology, 2019;597(8):2253-2268. DOI
- Wehrens SMT, Christou S, Isherwood C, et al. Meal timing regulates the human circadian system. Current Biology, 2017;27(12):1768-1775.e3. DOI
- Rishi MA, Cheng JY, Strang AR, et al. Permanent standard time is optimal for health and safety: a position statement from a sleep medicine learned society. Journal of Clinical Sleep Medicine, 2024;20(1):121-125. DOI



